UTERINE fibroids have been induced in the guinea-pig by the prolonged administration of oestrogen (Nelson, 1937a, 1937b; Moricard and Cauchoix, 1938). This finding acquired a more general interest from the point of view of the tumorigenic action of oestrogen in the body when it was discovered that fibroids can be elicited in this species not only on the uterus but on multiple

de un programa de ejercicio físico estructurado sobre los niveles de condición física y el estado nutricional de obesos mórbidos y obesos con comorbilidades. Nutr Hosp 2016;33:298-302 AbstractIntroduction: The increase of the physical condition collaborates to a decrease of the factors of risk of cardiovascular disease in morbid obese in morbid population. Objective: The purpose of this investigation was to evaluate the effects of a program of physical exercise on nutritional status and physical condition of obese and morbidly obese candidates for bariatric surgery. Material and methods: 18 women and 4 men between the ages of 18 and 60 year old candidates for bariatric surgery, 16 with morbid obesity and 6 with obesity and comorbidities were subjected to a program of physical exercise, with nutritional and psychological support during 5 months (3 session/week), before and 72 hours after the last meeting were evaluated: weight, body mass index (BMI), contour waist (CW), systolic and diastolic blood pressure, cardio respiratory fitness, bioenergetics, dynamic force maximum and hand grip strength. Results: The weight (p = 0.000), BMI (p = 0.000) and the CW (p = 0.000) showed significant changes with the intervention. Systolic and diastolic blood pressure did not improve significantly (p > 0.05). Cardio capacity, maximum dynamic force, hand grip strength and the bioenergetics capacity improved its levels reached statistical significance (p < 0.05). Conclusions: The intervention was feasible of developing, with high adhesion, it did not present risk for the health of the subjects and the physical condition increased significantly, in addition each 1 kg of weight lost there was a decrease of approximately 0,5 mmHg in systolic blood pressure and 1 cm in the contour waist, improving the conditions of the participants