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Abstract:The fermentation of little millet (Panicum sumatrense) carried out by probiotic yeast (Saccharomyces boulardii) and lactic acid bacteria (Lactobacillus acidophilus). The germinated little millets grains were fermented for 5 days grains were dried and grounded in a grinder and sieved. The sieved flours were analyzed for proximate composition, minerals and phytic acid content. The results showed that the little millet fermented by combined inoculation of Saccharomyces boulardii and L. acidophilus significantly enhanced protein content (10.95%) and decreases the fat (2.61%) and carbohydrate (82.01%) and single inoculation with L. acidophilus decreased the fibre (1.05%) and ash (2.30%). Single inoculation of L. acidophilus enhanced the minerals content Ca (41.44mg), Mg (141.08 mg), phosphorus (238.43mg), Fe (7.98 mg) and Zn (4.69mg) and over dual inoculation and control treatments. Similarly, Single inoculation of Lactobacillus acidophilus showed significant reduction in phytic acid (114.76 mg) content over dual inoculation (126.49 mg) and control (188.95 mg) treatments. The results indicated that fermentation of little millet by L. acidophilus enhanced mineral contents and reduction in phytic acid content.

Soybean (Glycine max (L) Merril). is also called Golden bean belongs to family Fabaceae is native to China having high nutritive value and oil content. Due to usage of inorganic fertilizers the fertility of soil and yield soybean has declined. Organic manures known to increase the soil fertility, structure and also influence the microbial enzymes activity and soil mesofauna. In this context the present investigation was undertaken to study, the different doses of farm yard manure and chemical fertilizers on the soil mesofauna and microbial enzymes at GKVK, Bangalore during the year 2013-2014. The investigation revealed that higher abundance of soil mesofauna (18.53) was recorded in 20 tons of FYMha-1 compared to the treatments with recommended package of practices (12.35) and inorganic fertilizer (10.30) alone. Soil mesofauna exhibited a significant positive relation with the microbial enzymes like dehydrogenase, acid and alkaline phosphtases and urease. The results of the multiple linear regression analysis showed that the influence of exchangeable calcium, available potassium and available phosphorous, exchangeable magnesium, dehydrogenase, alkaline phosphatase and urease on the abundance of soil mesofauna was up to 79 per cent. Higher rhizobium nodule number (64.93/plant) and yield (16.01 q/ha) of soybean found to increase with increase in farmyard manure application.

The integration of computational with various bioinformatics software/tools/webservers and the molecular docking process is the current key point method in reducing the time for drug discovery and drug development from a Bioactive compound. Current Insilco Study considers the Bioactive Phytoconstituents from Musa species for our drug discovery process by using bioinformatics software to find out the analogs by following their related physicochemical properties for the structure-based drug design. The gastric bacterium H. pylori infect the gastric mucosa, and its eradication is associated with the prevention of ulcer reoccurrence. The significant Protein target from this species was a challenging task for finding, targeting, treating. Offering hope from the Bioactive compounds considered in line with already FDA approved Drug molecules against peptic ulcer causative organism’s special protein vacuolating cytotoxin autotransporter translated from vacA Gene. The recent challenge is to identify a drug moiety that will effectively work on the target protein. Usually, the Phytocompounds will not significantly cause a side effect. Sitosterol with docking score of -6.417 kcal/mol has promised to serve as vacuolating cytotoxin autotransporter inhibitor by blocking the autotransporter protein to the periplasmic space avoiding the toxin passage between periplasmic membrane which will avoid the gastric infections from H. pylori.

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