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The strength distributions of the giant monopole resonance (GMR) have been measured in the even-A Sn isotopes (A=112-124) with inelastic scattering of 400-MeV alpha particles in the angular range 0 degrees -8.5 degrees . We find that the experimentally observed GMR energies of the Sn isotopes are lower than the values predicted by theoretical calculations that reproduce the GMR energies in 208Pb and 90Zr very well. From the GMR data, a value of Ktau = -550 +/- 100 MeV is obtained for the asymmetry term in the nuclear incompressibility.

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2-((1E,3E)-4-(6-( 11 C-methylamino)pyridin-3-yl)buta-1,3-dienyl) benzo [d]thiazol-6-ol ( 11 C-PBB3) is a clinically useful PET probe that we developed for in vivo imaging of tau pathology in the human brain. To ensure the availability of this probe among multiple PET facilities, in the present study we established protocols for the radiosynthesis and quality control of 11 C-PBB3 and for the characterization of its photoisomerization, biodistribution, and metabolism. Methods: 11 C-PBB3 was synthesized by reaction of the tert-butyldimethylsilyl desmethyl precursor (1) with 11 C-methyl iodide using potassium hydroxide as a base, followed by deprotection. Photoisomerization of 11 C-PBB3 under fluorescent light was determined. The biodistribution and metabolite analysis of 11 C-PBB3 was determined in mice using the dissection method. Results: 11 C-PBB3 was synthesized with 15.4% ± 2.8% radiochemical yield (decay-corrected, n 5 50) based on the cyclotron-produced 11 C-CO 2 and showed an averaged synthesis time of 35 min from the end of bombardment. The radiochemical purity and specific activity of 11 C-PBB3 were 98.0% ± 2.3% and 180.2 ± 44.3 GBq/μmol, respectively, at the end of synthesis (n 5 50). 11 C-PBB3 showed rapid photoisomerization, and its radiochemical purity decreased to approximately 50% at 10 min after exposure to fluorescent light. After the fluorescent light was switched off, 11 C-PBB3 retained more than 95% radiochemical purity over 60 min. A suitable brain uptake (1.92% injected dose/g tissue) of radioactivity was observed at 1 min after the probe injection, which was followed by rapid washout from the brain tissue. More than 70% of total radioactivity in the mouse brain homogenate at 5 min after injection represented the unchanged 11 C-PBB3, despite its rapid metabolism in the plasma. Conclusion: 11 C-PBB3 was produced with sufficient radioactivity and high quality, demonstrating its clinical utility. The present results of radiosynthesis, photoisomerization, biodistribution, and metabolite analysis could be helpful for the reliable production and application of 11 C-PBB3 in diverse PET facilities.

Multipole strength distributions for isoscalar L ≤ 2 transitions in 28 Si have been extracted using 386-MeV inelastic α scattering at extremely forward angles, including 0• . Observed strength distributions are in good agreement with microscopic calculations for an oblate-deformed ground-state. In particular, a large peak at an excitation energy of 17.7 MeV in the isoscalar giant monopole resonance (ISGMR) strength is consistent with the calculations.