CONTEXT:Several studies have reported that thrombophilia is responsible for recurrent pregnancy loss (RPL).AIMS:The aim of this study was to evaluate the prevalence and role of inherited thrombophilia in early pregnancy loss, specifically in the first trimester.MATERIALS AND METHODS:A total of 104 women (patients) with a history of two or more miscarriages during the first trimester of pregnancy and 110 women (controls) who had experienced two or more births without a miscarriage were included in this study. In both groups, we determined the biological activities of antithrombin III (ATIII) and protein C (PC) using the chromogenic method and the biological activity of protein S (PS) and the activated protein C resistance (APCR) were examined using a clotting method.RESULTS:In the patient group, deficiencies of ATIII, PC, and PS were detected in 3 (2.88%), 4 (3.85%), and 6 (5.77%) cases, respectively. In the control group, ATIII (0%) deficiencies were not detected, and deficiencies for PC (0.9%) and PS (0.9%) were each detected in 1 patient. APCR was detected in 9 patients (8.65%) and 4 control subjects (3.63%).CONCLUSION:Based on our results, we can conclude that thrombophilia is a causal factor for miscarriages in the first trimester of pregnancy, although there are the conflicting data in the literature.

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One of the most frequent hereditary causes of thrombophilia is, without a doubt, resistance to Activated Protein C (APC-resistance), which is a consequence of point mutation in gene coding for coagulation Factor V (Factor V Leiden) in - of cases. Th e aim of this paper was to determine prevalence of APC-resistance in a group of healthy blood donors. Th e size of the group is quite representative of Kosovo Albanians. A total of  blood donors were examined ( males and  females), for whom APC-resistance was determined by functional methods of coagulation using the kit ACTICLOT® Protein C Resistance. Method is based on the test of APTT determined twice: fi rst in the presence and second in the absence of activated Protein C (APC). Th e ratio of these two values constitutes is called Activated Protein C -Sensitivity Ratio (APC-SR). From  examined donors, pathologic values of APC-SR (,-,) were found in  persons (, of the total number). Th e distribution among sexes was , (/) in male and , (/) in female subjects. Th e mean values of APC-SR (, in male and , in female subjects) were not signifi cantly diff erent (P = ,). Based on these results, we conclude that the prevalence of APC resistance in Albanian population of Kosovo is within the lower limit of prevalence in general population in diff erent countries of European countries, which, according to some authors ranges is from  to .

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