In this study, we report the antimicrobial evaluation of newly synthesized amides of pyridoquinolones from substituted aniline, substituted phenyl thioureas and 4-amino-N-(substitutedphenyl)benzenesulfonamide. Structures of selected compounds have been established by IR and 1 H NMR spectra and elemental analysis. The structureactivity releationships have been studied by screening of antimicrobial activity over S. aureus, B. subtilis, E. coli, P. aeruginosa, and C. albicans using cup-plate method.

Synthesis of Amide Derivatives of Quinolone and Their Antimicrobial Studies. -A large variety of quinolinyl amides [cf. (IX), (XI); 70 examples] is synthesized. Several derivatives, e.g. (IXb)-(IXe), (XIa), exhibit significant antibacterial activity. -(PATEL, N. B.; PATEL, A. L.; CHAUHAN, H. I.; Indian J. Chem., Sect. B: Org.