Previous investigations (e.g. Gilligan, 1945; Krebs, Sykes & Bartley, 1947) have suggested that the metabolism of sulphamezathine (4:6-dimethyl-2sulphanilamidopyrimidine, I) was in general similar to that of other sulphonamides, acetylation being A~~~N CH3 H2N 802 meH CH3 (I)
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