We have carefully read the cohort study by Fu et al. on anti-osteoporosis medication (AOM) [1]. The authors reported that persistent anti-osteoporosis drug users have a lower risk of major fractures compared with patients who discontinued the treatment. The strengths of the study are its size and follow-up period from analyzing Taiwan's nationwide database (National Health Insurance Research Database [NHIRD]), which includes 99% of Taiwan's population.

Background: Lumbar facet joint has been considered a significant source of chronic low back pain (LBP). Radiofrequency (RF) lumbar facet denervation is an effective treatment modality for patients with lumbar facet syndrome (LFS). We propose this protocol to study the effect of RF and the change in serum beta-endorphin level in the treatment of LFS.