ExtractDuodenal biopsies from patients with acrodermatitis enteropathica were examined by electron microscopy and dissecting microscopy. T h e ultrastructural studies revealed characteristic inclusions in Paneth cells with a maximum length of 7 pm. These findings were constant in four different patients. A follow-up study in one patient showed the same alterations before and after treatment. SpeculationT h e biochemical defect of acrodermatitis enteropathica is unknown and, therefore, typical ultrastructural alterations challenge one to investigate the nature of the included material.

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There is an increasing number of reports on anaphylactic reactions due to latex. We report on a 9-year-old boy who developed anaphylaxis shortly after induction of anaesthesia due to a combined latex and ethylene oxide allergy. Patients with multiple medical treatment and those with atopy seem to be at risk.