A high-performance liquid chromatographic (HPLC) method for the determination of both aliphatic and aromatic isocyanates was first devised by Dunlap et al. using N-(4-nitrobenzyl)propylamine as the urea-forming reagent (nitro reagent). Subsequent w 0 r k ~9 ~ indicated serious disadvantages associated with the use of this reagent, including oxidation of the reagent both during and after sampling, deterioration of the HPLC column packing by excess of reagent in the samples and its unsuitability for sampling in a reducing atmosphere. These disadvantages appear to stem from the presence of the aromatic nitro group in this secondary amine.

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