Cycloadditions, 18. — 5‐Aminoisoxazoles by Cycloaddition of Nitrile Oxides to Ynamines
Ten differently substituted ynamines 1a–j react with five nitrile oxides 3a–e to give the 5‐aminoisoxazoles 4a–z. The stannyl‐substituted ynamine 1c furnishes the same compounds (e.g. 4a–d) by reaction with the hydroximoyl chlorides 2a–d. Two representatives of 4–b and p ‐ can be transformed into the corresponding 1‐azirine‐3‐carboxamides 6a and b.
The authors demonstrate a rare case of an adenocarcinoma of the uterus associated with a uterus septus. The concomitance of carcinoma and congenital uterine anomalies is coincidental and has no causal connection. Congenital anomalies of the uterus which remain undetected can be responsible for serious delay in diagnosis of carcinoma and may adversely interfere with treatment efforts.
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