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Gutta-percha solvents used during retreatment decreased the bond strength of Biodentine and CMTA to root dentin. The bond strength of WMTA was not affected by the use of gutta-percha solvents.

The aim of this paper is to report the healing of two large periapical lesions following non-surgical root canal treatment. The first case was a mandibular right lateral with periapical lesion of endodontic origin in a 40 year-old female patient with extra oral fistula and swelling. In the second case, a mandibular right central incisor was affected in a 22 year-old male patient. The root canals were prepared and filled with calcium hydroxide as an intra-canal medicament. The patients were recalled for clinical evaluation at intervals of 3 weeks. Root canals obturations were performed with gutta-percha and AH Plus sealer. The clinical and radiographic examination after 1 year revealed complete repair. This report confirms that large periapical lesions can respond favourably to nonsurgical treatment.