SUMMARY Regression equations were developed from left ventricular casts of known volumes to calculate left ventricular volumes from biplane cineangiography obtained in non-standard views. Volumes were calculated by Simpson's rule from casts of postmortem specimens from patients with congenital heart disease. The casts were divided into two groups: those that came from patients with abnormal right ventricular haemodynamic function (group 1, n = 11) and those that came from patients in which it was normal (group 2, n = 9). Biplane cinegrams were taken in conventional (anteroposterior/lateral, right anterior oblique/left anterior oblique) and nonconventional (long axis oblique, hepatoclavicular, and sitting up) projections. The true volume of each cast was determined from its weight and specific gravity. Correlations between measured and true volumes (r = 0-96 to 099) were excellent in all projections, although each projection overestimated the true volumes (slope = 0 72 to 0 94). The regression equations obtained from conventional views were significantly different from those from the non-conventional views; however, the regression slopes in group 1 were not different from those in group 2 in any view.Regression equations obtained by Simpson's rule do not seem to be affected by the haemodynamic state of the right ventricle. Different regression equations are required to measure left ventricular volumes from non-conventional angiograms.In angiographic measurement ofthe left ventricle the area-length method described by Dodge and colleagues has become popular.' This method was derived from the assumption that the left ventricular cavity could be represented as a three-dimensional ellipsoid of revolution. In complex congenital heart disease, however, the left ventricle is not usually elliptical and it is affected by right ventricular haemodynamic function. Data from our laboratory question whether the area-length method can be applied to the non-elliptical left ventricle.2Simpson's rule seemed to be independent of the Patients and methodsWe studied casts of the left ventricles of 20 hearts of children and infants who died of congenital heart disease. All clinical data and data on haemodynamic function were reviewed. There were four hearts with endocardial fibroelastosis; three with atrial septal defect; three with tetralogy of Fallot; two with complete transposition of great arteries with intact 182