An efficient synthesis of coniochaetone A and of racemate coniochaetone B was achieved by a short five-step procedure from methyl di-O-methyl-p-orsellinate. The key step is a cascade reaction of 2'-hydroxy-6'-methoxy-4'-methyl-2-(methylsulfinyl)-acetophenone with succindialdehyde in the presence of piperidine which allows the direct building of the tricyclic benzopyranone structure.
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