Clear cells are routinely encountered in the histopathological sections. They most frequently result from fixation artefacts; cytoplasmic accumulation of water, glycogen, lipids, mucins; hydropic degeneration of organelles, etc. When these clear cells predominate in a tumor, arriving at a definitive diagnosis becomes problematic. Thus, this review gives an idea of clear cells associated with various conditions, causes for clearing of these cells, clear cell tumors of the head and neck and a systematic approach towards arriving at an appropriate diagnosis of these tumors. How to cite this article Premalatha BR, Rao RS, Patil S, Neethi H. Clear Cell Tumors of the Head and Neck: An Overview. World J Dent 2012;3(4):344-349.

Background and objectives: Biochemical derangements of microelements although reported in oral cancer is poorly understood in oral submucous fibrosis (OSMF). Hence, the present study was carried out to estimate and compare the serum copper and zinc levels among different histopathological stages of OSMF with that of healthy controls.