The anti-oestrogen drug tamoxifen is an inhibitor of lipid peroxidation in rat liver microsomes and in phospholipid liposomes. Its cis isomer and N-desmethyl form are weaker inhibitors, but 4-hydroxytamoxifen is much more powerful. It is possible that the antioxidant property of tamoxifen might contribute to its biological actions.

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Summary. By virtue of their different sedimentation rates at unit gravity, different classes of erythroblast have been separated from the bone marrow of the anaemic rabbit. Each class of erythroblast has been characterized by morphological and biochemical criteria. The classes thus characterized form a series of cell types leading from the large immature erythroblast to the marrow reticulocyte. The fractionation procedure permits complete separation between erythroblasts which synthesize RNA and those which are no longer active in RNA synthesis.