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Summary[ 18 F]Cholesteryl 4-(fluoromethyl)benzoate 6b was prepared from 3-cholesteryl [(4-nitrobenzenesulfonyl)oxymethyl]benzoate in one step using K + -Kryptofix 2.2.2, as counter ion and acetonitrile as the solvent at 40-608C. The product was isolated by HPLC in 75% (decay corrected) radiochemical yield with a radiochemical purity of more than 90% in 30 min (specific radioactivity 2000-2500 Ci/mmol). Biodistribution studies in mice showed that a high target/non-target ratio of radioactivity was obtained in adrenal and ovaries.

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