A series of N-Mannich bases of benzimidazolyl substituted 1H-isoindole-1,3(2H) dione have been derived by the reaction of different substituted amino acids with phthalic anhydride to yield 2-(substituted) 1H-isoindole-1,3(2H) diones (3), further condensation with o-phenylenediamine yields 2substituted benzimidazolyl 1H-isoindole-1,3(2H) diones (4), followed mannich reaction with methanal and different amines to yields final products (5). The chemical structures of synthesized N-Mannich bases were determined by elemental analysis and spectral data (FTIR & 1 H NMR). All the synthesized derivatives have been evaluated for their antimicrobial, anthelmintic and insecticidal activities against microbes, helminthes and insects selected as compared to standard drugs by using disc diffusion method and Watkins technique respectively. All the synthesized N-Mannich bases possess the significant antimicrobial, anthelmintic and insecticidal activities.

In this paper a unique coincidence value is obtained for a class of self mappings satisfying non-expansive type condition on 2-metric spaces under various conditions and a fixed point theorem is also obtained. Mathematics Subject Classification: 54H25

Migraine has long been regarded as a vascular disorder because of the throbbing nature of the pain. Most patients with migraine require pharmacologic treatment. In the present research work sumatriptan succinate is used in the form of compressed core tablets via oral route of administration for effective treatment of migraine. The aim of this study was to reduce the dosing frequency and avoid hepatic first pass metabolism by preparing sumatriptan succinate loaded alginate microsphere. The microspheres were prepared by emulsification method. The prepared microsphere were characterized by scanning electron microscopy, and evaluated for different parameters like particle size, entrapment efficiency, polydispersity index, surface charge and in vitro drug release. The microsphere loaded compressed core tablets were prepared by direct compression method, where the drug loaded microsphere was present in the core of tablet. Further the outer coating layer was applied on the core of tablet that contains plain sumatriptan succinate to immediate release and provides instant relief from migraine symptoms. The formulations were evaluated for various parameters as well as in vitro drug release and compared with plain sumatriptan succinate loaded compressed core tablet. The in vitro drug release showed immediate drug release within 2 min from outer coating layer as well as sustained drug release for up to 24 h from core of tablet. It is concluded that the formulation provide instant as well as delayed release of drug to migraine patient which can decrease the dosing frequency and increase patient compliance.