The result supports the role of alcohol in colorectal carcinogenesis based on a Mendelian randomization approach.

No abstract

The results indicate that exercise training can prevent the attenuation of anesthetic cardioprotection in obesity. Preventing the attenuation of this strategy may be associated with reduced basal oxidative stress and normalized ROS-mediated AMPK pathway, but the causal relationship remains to be determined.

Background: Inherited thrombotic thrombocytopenic purpura (iTTP) is a rare autosomal recessive genetic disease caused by mutations in the ADAMTS13 gene, including homozygous and heterozygous gene mutations. The annual incidence of this genetic disease is less than 1/1000000, and women are more common which the incidence rate is about twice that of men. Five signs and symptoms of iTTP are thrombocytopenia, micro-angiopathic hemolytic anemia, renal failure, fever and neurologic deficits, which caused by the combination of genetic factors and environmental factors which mainly contain pregnancy and infection. Plasma ADAMTS13 activity and ADAMTS13 gene sequencing can be tested in the laboratory, and the plasma ADAMTS13 activity <10% is a diagnostic criteria in the guidelines. About 80 mutations in the ADAMTS13 gene have been identified, including missense mutations, nonsense mutations, deletions or insertion mutations.