A novel synthetic strategy for highly enantioenriched cis-3,5-disubstituted γ-lactones has been developed by the AgOTf-promoted nucleophilic substitution of α-bromoacetates with silyl enol ethers and subsequent reductive lactonization. The utility of...
Modular three-component synthesis of highly enantioenriched 2,4,6-trisubstituted dihydropyridazinones was developed through the nucleophilic substitution of α-bromoacetates with silyl enol ethers and subsequent condensation with hydrazine derivatives.
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