Cytotoxic phenolic constituents from the leaves of Ehretia asperula Sir, The genus Ehretia is mainly distributes in tropical areas of Asia, Africa, Northern America and exhibited valuable pharmacologial properties (Li et al., 2010; Shukla and Kaur, 2018). In Vietnam, Ehretia asperula Zoll. & Mort. has been used in traditional medicine for the treatment of ulcer, tumors, liver disease and inflammation (Nguyen et al., 2017). To date, there are few reports about the biological activities and chemical composition of this plant.