Protein array analysis showed that in response to NTHi or S. pneumoniae, rat SLFs released monocyte chemotactic protein 1, macrophage inflammatory protein 3 alpha, TNF-alpha, and cytokine-induced neutrophil chemoattractant 2 and 3. Treatment with IL-1alpha, on the other hand, resulted in release of MCP-1 but not the other molecules. Tissue inhibitor of metalloproteinase 1 and vascular endothelial growth factor were released regardless of the inflammatory stimulus used.

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؊ cattle at 2 h p.i. was significantly higher than that of CD18 ؉ cattle; at 4 h p.i., there was no difference between the two groups. These data suggest that ␤ 2 -integrins may contribute to the induction of expression of some PIC genes, as a consequence of P. haemolytica infection.

Introduction 31 Materials and Methods 31 Animals and Escherichia culi inoculation 31 Analysis of milk samples Probe synthesis for in situ hybridization In situ hybridization Data analysis Results Discussion 35