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Sindrom Koroner Akut (SKA) merupakan puncak manifestasi klinis aterosklerosis di arteri koroner. Inflamasi terjadi dari tahapawal pembentukan ateroma sampai ruptur plak dan trombosis. Trombosis memainkan peran penting dalam perjalanan penyakit SKA.Trombositosis dan limfopenia berhubungan dengan derajat inflamasi sistemik dan Rasio Platelet Limfosit (PLR) menjadi petanda baruyang melibatkan kedua tolok ukur hematologi tersebut. Penelitian ini merupakan penelitian retrospektif di Rumah sakit Dr. WahidinSudirohusodo Makassar dengan mengambil data pasien SKA UAP, STEMI, NSTEMI dan menilai PLR dari pemeriksaan darah rutin saatmasuk Rumah sakit. Data PLR dibandingkan berdasarkan jenis SKA, kemudian dibandingkan dengan kontrol sehat. Hasil penelitiandidapatkan 223 data pasien SKA UAP, STEMI dan NSTEMI masing-masing 89, 68, 66 data dan kontrol normal 198 data. Hasil ujistatistik Kruskal wallis menunjukkan perbedaan bermakna PLR antara pasien UAP, NSTEMI dan STEMI (p=0,011). Hasil uji post hocmenunjukkan perbedaan bermakna antara UAP dan NSTEMI (p=0,023), UAP dan STEMI (p=0,006), tetapi tidak berbeda bermaknaantara NSTEMI dan STEMI (p=0,827). Nilai PLR pasien SKA lebih tinggi dibandingkan dengan pembanding (p=0,037). Berdasarkanhasil penelitian didapatkan nilai PLR meningkat di SKA dibandingkan dengan kontrol normal. Nilai PLR di STEMI dan NSTEMI lebihtinggi dibandingkan UAP, kemungkinan berhubungan dengan pembentukan trombus dan infark miokard.

BACKGROUND: Early detection of risk factors for pregnancy is carried out through regular prenatal examinations from an early age to detect abnormalities/disorders/illnesses suffered by pregnant women early. Mobile applications are very helpful in the process of early detection and recording of health workers’ reports, especially during a pandemic. AIM: This study aims to assess the knowledge, attitudes, actions, and skills of pregnant women in the early detection of high-risk pregnancy before and after the intervention and the effectiveness of M.D-Risti modules and applications. METHODS: This study used a quasi-experiment design research design with a pre-post only group design consisting of an intervention group and a control group at 4 health centers in Palu City with a purposive sampling technique of 43 respondents per group with univariate and bivariate analysis. RESULTS: The results showed that there was a significant difference in the level of knowledge (p = 0.00), attitude (p = 0.00), action (p = 0.00), and the skills of pregnant women in early detection of pregnancy (p = 0.00) before and after treatment in the intervention group. There was a significant difference between the two groups with a significant value on knowledge (p = 0.00), attitude (p = 0.00), action (p = 0.00), and skills of pregnant women in doing early detection of pregnancy risk independently (p = 0.00). CONCLUSION: The intervention of M.D-Risti modules and applications had a significant effect on changes in knowledge, attitudes, actions, and skills of pregnant women in early detection of pregnancy risk compared to pregnant women who were not given intervention at all. The M.D-Risti application is one of the solutions during the COVID-19 pandemic and in the long term, all health centers in Palu city can use it to help monitor the risk of pregnancy more quickly

BACKGROUND: Around 2.6 billion people lack proper sanitation. In addition, nutritional problems such as multiple micronutrient (MMN) deficiency can increase morbidity, mortality, and impaired neurocognitive growth at later stages of life. In addition to the need for a sanitary approach, a globally applicable strategy to prevent micronutrient deficiencies in pregnant women, UNICEF recommends the use of MMN for prenatal supplementation as an initial program in developing countries, to reduce the risk of poor birth outcomes. AIM: The aim of this literature study was to analyze the relationship between sanitation and the multimicronutrient (MMN) approach in pregnancy and birth outcomes. METHODS: This research was conducted using literature review method. Various references were collected from online database including reports, journals, and books. The journals were mostly from the scholarly journals. The articles were screened according to the research objectives. The keywords used are sanitation, pregnancy, and multiple micronutrient approach. RESULTS: Several studies have shown that sanitation and the multi micronutrient (MMN) approach play a role in determining pregnancy outcomes. We conclude that the importance of sanitation on pregnancy outcome is to reduce the chance of infection. The importance of MMN in pregnancy outcomes is that mothers who consume MMN during pregnancy can reduce the risk of poor birth output. The role of stakeholders is needed in the future. CONCLUSIONS: Several studies have shown that sanitation and multi micronutrient (MMN) play a role in determining pregnancy outcome.

Diabetes Mellitus (DM) is a chronic inflammatory disease characterized by hyperglycemia and increasing the neutrophil-lymphocyte ratio (NLR). Metformin has been widely used to treat hyperglycemia. Metformin nanoparticles can improve bioavailability and may reduce inflammation. This study aims to analyze the effectiveness of metformin nanoparticles delivery through fasting blood glucose (FGB) level and NLR in the diabetic rat model. This study used 16 white male Wistar rats, 8 weeks of age, and body weight (BW) 250-350 grams. The streptozotocin (STZ) 40 mg/kg BW were injected i.p. Rats were divided into 4 groups; K1: normal control; K2: negative control (diabetes model); K3: diabetes model treated with metformin 100mg/Kg BW; K4: diabetes model treated with nanoparticle metformin 100mg/kg BW. Blood analysis tests were conducted using the Pentra hematology analyzer. Data were analyzed using the Graphpad Prism program with the nonparametric Kruskal Wallis test. The K3 group showed a periodical decrease in FBG level from day 7 to day 28 by 122 ± 11.31 mg/dL, and the mean NLR value was 0.48 ± 0.3 x 103/uL. Group of K4 periodically decreased in FBG level, indicating that it was closer to normal than K3. The result showed that at day 28.79 ± 15.39 mg/dL, the mean NLR value slightly increased compared to the K3 group by 0.54 ± 0.3 x103/uL. The statistical tests showed a significant difference between the level of FBG (p 0.0089) but no significant difference in NLR (p 0.347). Metformin nanoparticles could decrease FBG levels and effectively reduce the NLR in the diabetic rat model.