MMPs are Zn dependent proteases. All of MMPs kind is multi-domain proteins and their activities are regulated by tissue inhibitors of metalloproteinases. The prevention of the pathologies which is created by MMPs used some synthetic and naturally inhibitors. This review will explain the attitude MMPs and some chemical and physical factors which to being high level and low could affect to MMPs activity and synthesis as caffeine, one of snake venom components, melatonin, serotonin, stress factor, E and C vitamins.

MMPs are Zn dependent proteases. All of MMPs kind is multi-domain proteins and their activities are regulated by tissue inhibitors of metalloproteinases. The prevention of the pathologies which is created by MMPs used some synthetic and naturally inhibitors. This review will explain the attitude MMPs and some chemical and physical factors which to being high level and low could affect to MMPs activity and synthesis as caffeine, one of snake venom components, melatonin, serotonin, stress factor, E and C vitamins.

No abstract

The danger of COVID-19 infection is its higher contagiousness (several times higher than influenza), a long incubation period (up to 14 days), and is complicated by the fact that patients without any symptoms are carriers of the infection. Currently, the clinical and epidemiological researches on the characteristics of the disease continue, along with the development of the new means of its prevention and treatment. The most important preventive resource is the activation of the antiviral innate immune system. According to the literature, an adequate supply of vitamin D is one of the foundations of the antiviral immune system, including against the influenza virus. No clinical trials have been conducted to determine the relationship between vitamin D blood level and clinical outcome in COVID-19 patients. To study the effect of blood levels of vitamin D in patients infected with COVID-19 on the course of the disease and the outcome of treatment, a medical history of 19 patients with laboratoryconfirmed COVID-19 infection was analyzed. The patients were treated at the «MediClub» LLC between 15.06.2020-15.07.2020. «MediClub» hospital was approved by «TABIB» Azerbaijan for the treatment of patients with COVID-19. Data on clinical manifestations and blood 25hydroxyvitamin D [25(OH)D] levels were obtained from all medical histories. A retrospective analysis of laboratory-confirmed cases of COVID-19 showed a relationship between the blood level of 25-hydroxyvitamin D [25(OH)D] and the nature of the course of COVID-19 and the development of complications of the disease. Taking into account the main cause of critical complications of COVID-19 is impaired immunity, and cholecalciferol harmonizes the functioning of the immune system at all its levels, it can be concluded that an adequate level of vitamin D in the blood increases the likelihood of a light course of COVID-19 and its favorable outcome.

There are lots of factors which can be a cause for cardiovascular disease including obesity, smoking, genetic factors, drug product, abnormal lipid metabolism and etc. Cardiovascular diseases spread all over the world and the death rating risk of cardiac disease is getting higher. That's why the cause of cardiovascular disease must be known to overcome cardiac disease and for this reason, this review article was considered inevitable and we will be talking about the structure of human cardiac cells and the basic cause of cardiovascular disease.