Objective: The aim of this study was to evaluate the histopathological changes in the nephrectomy specimens. Study Design: Retrospective study. Setting: Private Lab, Located in Faisalabad. Period: January 2015 to December 2019. Material & Methods: A total of 113 cases were included in the study. In this study paraffin blocks and previous slides along with clinical data were analyzed according to standard protocols. Patient age, sex and histological diagnosis were noted and compared. Results: In this study we analyzed 113 cases, received during a five year time period. Out of which 60 (53%) were males and 53 (47%) were females. Most common age group ranges from 51 to 60 years and the least common affected group was 71 to 80 years. The neoplastic cases were 66 (58%) and nonneoplastic cases were 47(42%). Neoplastic were further sub- divided in to 3(5%) benign cases and 63(95%) malignant cases.  Most common neoplastic lesion was clear cell renal cell carcinoma, 49 (74%) cases and most common non- neoplastic condition was chronic pyelonephritis, 37 (78%) cases. Conclusion: Nephrectomy is the ultimate surgical procedure for the treatment of renal diseases. The 5th to 6th decade is the most common age group of patients affected by non- neoplastic conditions leading to non-functioning kidney. Malignant tumor like clear cell carcinoma is the most common malignant tumor in our society. Early clinical, radiological and histopathological diagnosis of renal diseases will help out patients for proper management. Thus every nephrectomy specimen should be evaluated through clinico –pathological correlation.