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To Lich River is well-known as a main drainage river and plays a vital role to the landscape distribution of Hanoi city, which is currently polluted due to improperly untreated wastewater flow. Thanks to QUAL2K model, the variation of river water quality has been forecasted by 4 particular scenarios. For the first scenario, the whole generated wastewater along To Lich River is not totally collected and treated. For the second one, it occurs as the former one with an addition of diluted water of 5m3/s from Red river. Next, wastewater is mostly well managed but minor sources are not collected. Finally, the whole generated wastewater is properly treated and added with a diluted amount of 5m3/s from Red river. The study indicated that in order to meet standard of column B1, QCVN 08-MT:2015/BTNMT (Vietnam National Regulation), centralized and decentralized generated sewerage is required the appropriate treatment to reach column B National Standard 02:2014/BTNMT, with the BOD5 is lower than 20 mg/L before discharging into the nature.