Diverse clustered protocadherins are thought to function in neurite morphogenesis and neuronal connectivity in the brain. Here, we report that the protocadherin alpha (Pcdha) gene cluster regulates neuronal migration during cortical development and cytoskeletal dynamics in primary cortical culture through the WAVE (Wiskott-Aldrich syndrome family verprolin homologous protein, also known as Wasf) complex. In addition, overexpression of proline-rich tyrosine kinase 2 (Pyk2, also known as Ptk2b, Cakβ, Raftk, Fak2, and Cadtk), a non-receptor cell-adhesion kinase and scaffold protein downstream of Pcdhα, impairs cortical neuron migration via inactivation of the small GTPase Rac1. Thus, we define a molecular Pcdhα/WAVE/Pyk2/Rac1 axis from protocadherin cell-surface receptors to actin cytoskeletal dynamics in cortical neuron migration and dendrite morphogenesis in mouse brain.

The growing demands for optical anti-counterfeiting technology require the development of new environmentally friendly materials with single component, multimodal fluorescence and high stability. Herein, the Bi/Sb codoped Cs2Ag0.1Na0.9InCl6 lead-free double perovskite material is reported as an efficient multimodal luminescence material with excitation-wavelength-dependent emission. When excited by 360 nm UV light, dual-emission is observed at 455 and 560 nm, which comes from the 3P1–1S0 transition of Sb3+ ions and self-trapped excitons (STEs), respectively. Under the 320 nm UV lamp, the microcrystals show only a blue emission centered at 455 nm. Therefore, the Bi/Sb codoped Cs2Ag0.1Na0.9InCl6 double perovskite emits blue and yellow lights under the 320 and 360 nm UV lamp, respectively. Moreover, the obtained double perovskite shows a high PLQY up to 41% and excellent stability against both air and high temperature, which make it a promising anti-counterfeiting material.