In addition to associations with older age, increasing myopia, and larger disc size, the EDI-OCT-defined gamma zone of parapapillary atrophy was associated with the absence of glaucoma, whereas the EDI-OCT-defined beta zone was associated with the presence of glaucoma. Differentiation between the beta zone and the gamma zone may be clinically useful.

PURPOSE.To determine the effect of travoprost 0.004% on Schlemm's canal (SC) in healthy human eyes using Fourierdomain optical coherence tomography (FD-OCT).METHODS. Twelve healthy volunteers were recruited for a double-blind, placebo-controlled, randomized, and paired comparison study. Right eyes of subjects were randomly assigned to receive either travoprost 0.004% or placebo; the contralateral eye received the other treatment. FD-OCT imaging of SC and measurements of IOP were carried out before and at 1, 2, 4,6,8,12,24,36, 48, 60, 72, and 84 hours after eye drop instillation.RESULTS. After instillation of travoprost eye drops, IOP gradually reduced, and the SC lumens expanded, while those values remained unchanged in placebo treated eyes. At 8 hours after the travoprost administration, the mean SC area increased 90.30% and 90.20%, respectively, in the nasal and temporal quadrant of the treated eyes as compared with the placebo group. The SC area and IOP showed a similar pattern of changes at most time points examined. In travoprost-treated eyes, a statistically significant correlation between SC area and IOP is observed (r ¼ À0.2817; P ¼ 0.0004). Measurements of the SC area showed sufficient repeatability and reproducibility.CONCLUSIONS. SC can be noninvasively imaged and quantitatively assessed in the living healthy human eye by FD-OCT. Travoprost treatment leads to SC lumen expansion accompanied by a drop of IOP in the healthy eye, likely as a result of the enhancement of pressure sensitive trabecular meshwork outflow induced by travoprost. (Invest Ophthalmol Vis Sci.

The pattern of perimetric loss was associated with the CRVT position: eyes with a central visual field island tended to have the CRVT in the temporal optic disc region.

The mGCC measurements provide another measurement of neural loss in glaucoma, and may serve as a promising parameter for ppNFL thickness in the clinical assessment of glaucoma. For glaucomatous eyes, mGCC and ppNFL thicknesses performed better discriminating abilities compared with macular thickness.