Urtica dioica is used in the many countries as seasoning and as an herbal medicine (antioxidant). In this study, adult male locale rabbit was separated into five groups, group 1 considered as control, group 2 to 5 animals were treated with 0.75% ethylene glycol (EG) in water to induce renal and liver damage till 30 th day. The group 3 to 5 animals were feed extract of the plant of U. dioica at a dosage of 100 mg/kg body weight from day 15 to the day 30. The extracts were administered twice daily orally. Liver histopathological changes characterized by vacuolar degeneration and coagulative necrosis of hepatocytes, congestion and dilatation of central vein and sinusoids. Renal histopathological changes characterized by deposition of oxalates, blood vessels congestion infiltration of inflammatory cells and change in renal glomeruli in GE treated groups. While histopathological changes in the animals group treated with U. dioica extract and ethylene glycol showed an increase improvement of the histological features of liver tissue, were limited dilatation of renal tubules with less deposition of oxalates, as well as slight infiltration of inflammatory cells in the interstitial tissue. Finally, as a conclusion we noticed that U. dioica extracts had the ameliorative effect of ethylene glycol-induced hepatic and renal histopathological.