Methods We conducted a monocentric retrospective study that included all patients diagnosed with a gestational trophoblastic neoplasia over a period of 18 years. It took place in the gynecology and obstetrics department of the hospital of Ben Arous. We studied the patients features and characteristics. Results We registered 204 cases of gestational trophoblastic disease (GTD) during the period of the study including: 189 (92.65%) cases of hydatidiform mole and 15 (7.35%) cases of gestational trophoblastic neoplasia (GTN). Three patients were diagnosed with choriocarcinoma. Two of them had placental site trophoblastic tumor and one patient had an invasive mole. Only two patients had a metastatic disease. The incidence of GTN was 2.7 cases per 10000 deliveries and 2.6 per 10000 pregnancies. The mean age of our patients was 30.6 years old . Most patients were pauciparous. Three of them had a perimenopausal status. History of spontaneous abortion was found in 5 cases. A history of hydatidiform mole was found in 12 cases. All pregnancies were spontaneous. Conclusions Gestational trophoblastic neoplasia is rare and has wide incidence variations worldwide. Maternal age and history of hydatidiform mole have been identified as risk factors but the definitive mechanism is not well known.