Objectives. NLR (neutrophil-lymphocyte ratio) and PLR (platelet-lymphocyte ratio) are prognostic markers of diff erentiated thyroid cancers. In our study, we evaluated NLR, PLR and C-reactive protein (CRP) for predicting the occurence of diff erentiated thyroid cancer. Th is is the fi rst study that compares NLR and PLR to C-reactive protein indiff erantiated thyroid cancer not only papillary cancer but also folliculer cancer.Methods. Th is study includes 51 papillary carcinoma, 42 papillary microcarcinoma and 31 folliculer carcinoma patients attending to our outpatient Endocrinology Clinic at Erzurum Region Training and Research Hospital between 2009 and 2014. Th e control group include 50 age, sex and body mass index matched healty subjects. Blood counts and CRP were measured at the day before surgery. Th yroglobulin was measured aft er 6 months of operation.Results. Th ere were positive correlations between tumor diameter, age, white blood cell (WBC) and thyroglobulin levels. Th ere were also positive correlation between NLR, PLR and CRP levels.Conclusion. In our study, we found out that higher NLR and PLR was associated with higher levels of thyroglobulin which indicates worse survival. CRP levels were also associated with poorer tumor profi le but the determining rate was lower according to ROC analysis

Objective. Th e neutrophil-lymphocyte ratio (NLR), determined from peripheral blood, is accepted as an available and practical indicator of the systemic infl ammation. In this study, we aimed to determine whether the NLR was higher in euthyroid chronic autoimmune thyreotidis (CAT) patients compared to a healthy control group.Methods. A total of 112 patients were enrolled in this study, including 59 patients with euthyroid CAT on any form of therapy and 53 healthy controls. Th e CAT patients were similar in age to the healthy control group (mean 33.9±12.8 years versus 30.2±12.4 years, p=0.10). Measurements were available for the white blood cells (WBC), neutrophils, lymphocytes, platelets, C-reactive protein (CRP), thyroid peroxidase immune antibody (anti-TPO), and anti-thyroglobulin immune antibody (anti-TG). Th e NLR and platelet-lymphocyte ratio (PLR) were calculated. Diff erences between the CAT and control groups were tested using the student's t-test and the correlations were determined using Pearson's correlation coeffi cients.Results. Th ere were no diff erences between the CAT and control groups for WBCs (7.9±0.3 and 7.4±0.2, respectively; p=0.1) or neutrophils (5.5±0.3 and 5.4±1.1; p=0.9), but lymphocytes were higher in the CAT group (3.1±0.5 vs. 2.04±0.1; p=0.05) as was the NLR (4.0±0.7 vs. 2.0±0.1; p=0.01). Th e NLR was positively correlated with CRP (r=0.6, p<0.001), anti-TPO (r=0.3, p<0.001), anti-TG (r=0.3, p=0.006), WBCs (r=0.4, p<0.001), and the PLR (r=0.73, p<0.001). Th e PLR was also higher in the CAT than the control group (p=0.02).Conclusions. In this study, we found that NLR values were higher in euthyroid CAT patients than in a healthy control group and that NLR correlated with autoantibodies used to diagnose the disease.

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Polikistikover sendromu (PKOS) üreme çağındaki kadınları etkileyen en sık endokrin bozukluktur. Klinik ve biyokimyasal özellikleri metabolik sendrom ile benzerlik göstermektedir. Metabolik sendromlu hastalarda insülin direnci, serum ürik asit düzeyi ile ilişkilidir. Çalışmamızda PKOS hastalarında serum ürik asit düzeylerinin laboratuar ve klinik ile ilişkisini incelemeyi amaçladık. Gereç ve Yöntemler: Hastanemiz Endokrin Kliniğin'de takip edilen 172 PKOS hastası, 34 yaş ve vücut kitle indeksi (VKİ) uyumlu kontrol grubu toplam 206 olgu katılmıştır. Erken folliküler fazda, 12 saat açlık sonrası kan örnekleri alınmıştır. Bazal serum hormon düzeyleri immunoassay ile değerlendirildi. Bulgular: Ürik asid düzeylerinin PKOS grubunda kontrol grubuna göre istatistiksel olarak anlamlı bir şekilde daha yüksek saptanmıştır (4,25 ± 1,07 PKOS, 3,7 ± 0,79 kontrol, P = 0,048). Ürik asit ile VKİ, total kolesterol, insülin, siklus süresi, Ferriman Gallwey skoru arasında pozitif anlamlı korelasyon, HDL kolesterol ile anlamlı negatif korelasyon bulunmuştur. Çok değişkenli logistik regresyon yapıldığında ürik asit düzeylerinin PKOS grubunda yaş ve VKİ'den bağımsız olarak iki kat daha yüksek olduğu saptanmıştır. Sonuçlar: Çalışmamızda PKOS grubunda ürik asit düzeyleri anlamlı bir şekilde yüksek bulunmuş ve bu yüksekliğin yaş ve VKİ'den bağımsız olduğu görülmüştür. Ürik asit ile kardiyovasküler risk faktörü olan kolesterol, Trigliserit, VKİ, insülin arasında pozitif korelasyon görülmüştür. Klinik gösterge olan Ferriman Gallwey, siklus süresi açısından da pozitif korelasyon saptanmıştır. Artmış ürik asit düzeyleri PKOS hastalarında kardiyovasküler hastalık oluşumu için bağımsız bir risk faktörü olabilir, klinikte olumsuz sonuçları gösterebilir.