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We report here a 44-year-old Moroccan man with resectable gastric adenocarcinoma with overexpression of human epidermal growth factor receptor 2 (HER2) by immunohistochemistry who was treated with trastuzumab in combination with chemotherapy in perioperative setting. He received 3 cycles of neoadjuvant chemotherapy consisting of trastuzumab, oxaliplatin, and capecitabine. Afterwards, he received total gastrectomy with extended D2 lymphadenectomy without spleno-pancreatectomy. A pathologic complete response was obtained with a combination of trastuzumab and oxaliplatin and capecitabine. He received 3 more cycles of trastuzumab containing regimen postoperatively.We conclude that resectable gastric carcinoma with overexpression of the c-erbB-2 protein should ideally be managed with perioperative combination of trastuzumab with chemotherapy. Further research to evaluate trastuzumab in combination with chemotherapy regimens in the perioperative and adjuvant setting is urgently needed.

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Les tumeurs pseudopapillaires et solides du pancréas (TPPSP) sont des tumeurs rares, d'étiopathogénie encore incertaine, et surviennent surtout chez la jeune femme. Leur extension locale et à distance est rare, et leur pronostic reste bon surtout après exérèse complète. Nous rapportons une nouvelle observation chez une jeune femme, révélée par une douleur. L'échographie et le scanner ont permis de poser le diagnostic. Le traitement chirurgical était conservateur et consistait à une tumorectomie. L'étude histologique confirma le diagnostic de TPPSP. Mots clés Pancréas · Tumeur papillaire et solide · Résection chirurgicaleAbstract Solid pseudopapillary tumors (SPT) of the pancreas are rare exocrine pancreatic tumors. Their etiology is unknown and they occur most commonly in young women. Local invasion and metastatic evolution is rare in these tumors and their prognosis is excellent after complete surgical resection. We report of SPT in a young female revealed by abdominal pain. The diagnosis of the cystic tumor was based on abdominal ultrasound and CT data. The surgical treatment was conservative and consisted of a tumorectomy. Histological study confirmed the diagnosis of SPT of the pancreas.

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