Ischemia-reperfusion (IR) injury is an important cause of liver damage in liver transplantation or liver resections with the Pringle maneuver, and it is the main cause of liver dysfunction (1). Unfortunately, the mechanism of damage is not exactly known, but an inflammatory and oxidative process is proposed in the complex pathophysiology. Many molecules have been studied in animal experiments to reduce hepatic damage, but the improvements are not sufficient.Quercetin is a flavonoid found mostly in fruits and vegetables. Epidemiological studies with quercetin were started in the 1990s. The molecule is found in a wide variety of plants, such as apples, onions, and berries and in red wine. Quercetin has antioxidative, anti-inflammatory, antiaggregatory, and anticarcinogenic effects (2).The present study was designed to evaluate the effects of quercetin on hepatic IR injury of rats formed by the Pringle maneuver. Methods Experimental design and animalsThis study was performed according the "Guide for the Care and Use of Laboratory Animals" (National Research Council Institute for Laboratory Animal Research, US, Washington, National AcadProtective effects of quercetin on hepatic ischemia reperfusion injury Quercetin'in karaciğer iskemi reperfüzyon hasarı üzerine koruyucu etkisi Introduction: The present study was designed to evaluate the effects of quercetin on hepatic ischemia-reperfusion injury of rats formed by the Pringle maneuver.Methods: Five-to-six-month-old, 24 female Wistar-Albino rats weighing 200-250 mg were used in this study. In the sham group, 15 minutes after anesthesia induction, laparotomy was performed. Ischemia was not created. In the other groups, the hepatic pedicle (portal vein, hepatic artery, and bile duct) was explored and ischemia was created using an atraumatic microvascular clamp. Meanwhile, the exposed abdomen was covered with warm gauze soaked in saline. In the study group, quercetin was injected intraperitoneally prior to laparotomy and ischemia-reperfusion. Liver tissue samples from the left lobe were analyzed under a light microscope for liver damage. For the evaluation of hepatic ischemia-reperfusion injury and the assessment of quercetin's effect on the antioxidant systems, total oxidant status and total antioxidant status levels were measured. The oxidative stress index was calculated.Results: Aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase values of the control group were significantly higher than those of the sham and study groups (p<0.001). Although the mean total antioxidant status, total oxidant status, and oxidative stress index values of the study group were found to be lower than those of the control group, the difference was not statistically significant (p>0.05). Significantly less vacuolization and sinusoidal dilatation were observed in the study group compared to the control group (p<0.05). For necrosis and apoptosis, no significant difference was observed between the control and study groups (p>0.05). Conclusion:Quercetin, which hosts ma...

Traumatic rectal injuries are rare entities with increased morbidity and mortality. In traumatic rectal injuries, primary repair is preferred in patients with early diagnosis, whereas inclusion of fecal diversion could reduce the morbidity and mortality in patients with generalized peritonitis. In this article we report a case of rectum perforation that occured due to blunt abdominal trauma. This perforation had been primarily sutured. Postoperative course was favorable without any wound infection or intraabdominal sepsis. Keywords: Trauma, injury, rectumReceived :31.12.2010 Accepted: 03.01.2011 ÖZETTravmatik rektum yaralanmaları nadir görülen, morbidite ve mortalitesi yüksek, cerrahi tedavisi halen tartışmalı bir klinik antitedir. Travmatik rektum yaralanmalarında erken tanı konulan hastalarda primer tamir, generalize peritonitin eşlik ettiği hastalarda primer tamir ve saptırıcı stoma uygulanması mortalitesi ve morbiditesi düşük yaklaşımlardır. Biz bu makalede, rektum perforasyonu ile sonuçlanan künt batın travmalı bir olguyu sunmaktayız. Perforasyon primer sütür ile onarıldı. Postoperatif dönemde yara yeri enfeksiyonu veya intraabdominal sepsis ile karşılaşılmadı.

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