This paper focuses on the use of natural sources for the preparation of efficient and low cost catalysts for triazole synthesis.

A variety of 1-aryl-1,2,3-triazoles containing heteroarenes at C2-, C3-or C4-positions on the aryl ring was successfully prepared via palladium-catalysed direct arylation. These couplings were performed employing 1 mol% of phosphine-free Pd(OAc) 2 catalyst with 1-(bromophenyl)-1,2,3-triazoles and heteroarenes as coupling partners. A wide variety of heteroarenes such as thiazoles, thiophenes, furans, pyrroles or isoxazoles was tolerated.