The sodium alginate-g-poly(acrylic acid-co-acrylamide)/rice husk ash (NaAlg-g-P(AA-co-AAm)/RHA) superabsorbent nanocomposite was synthesized by the free-radical graft copolymerization of alginate (NaAlg), acrylic acid (AA), acrylamide (AAm), and RHA in aqueous solution. FTIR spectra revealed that the monomers were grafted onto NaAlg chains, and the nanocomposite was formed successfully. Incorporation of RHA into hydrogel matrix formed porous interlinked channels within hydrogel network. Superabsorbent nanocomposite showed greater equilibrium swelling capacity (1070g/g) compared with neat hydrogel (830g/g). Moreover, water transport mechanism of all hydrogels was non-Fickian diffusion type. Rheological measurements confirmed effective role of RHA in improving gel strength of superabsorbent nanocomposite. The influence of various factors, such as different loads (0.3, 0.6, 0.9 psi), solution pH, saline solution, and temperature on the swelling behavior of hydrogels was also assessed. Superabsorbent nanocomposite exhibited good pH-dependent swelling reversibility and high water retention capability, making it more efficient water-saving material for agricultural and horticultural applications.
Purpose: In this study, we aimed to prepare an extended drug delivery formulation ofclarithromycin (CAM) based on a semi-interpenetrating polymer network (semi-IPN) hydrogel.Methods: Synthesis of semi-IPN hydrogel nanocomposite made of chitosan (CS), acrylicacid (AA), acrylamide (AAm), polyvinylpyrrolidone (PVP), and montmorillonite (MMT) wasperformed by free radical graft copolymerization method. Swelling kinetic studies were done inacidic buffer solutions of hydrochloric acid (pH = 1.2), acetate (pH = 4), and also distilled water.Also, the effects of MMT on the swelling kinetic, thermal stability, and mechanical strengthof the hydrogels were evaluated. Moreover, in vitro release behavior of CAM and its releasekinetics from hydrogels were studied in a hydrochloric acid buffer solution.Results: Fourier transform infrared spectroscopy (FTIR) results revealed that synthesis of semi-IPN superabsorbent nanocomposite and CAM incorporation into hydrogel was performed,successfully. Introducing MMT into hydrogel network not only improved its thermal stabilitybut also increased mechanical strength of the final hydrogel product. Also, in comparisonwith neat hydrogel (1270 g/g), hydrogel nanocomposite containing 13 wt% MMT exhibitedgreater equilibrium swelling capacity (1568 g/g) with lower swelling rate. In vitro drug releaseexperiments showed that CS-g-poly(AA-co-AAm)/PVP/MMT/CAM formulation possesses asustained release character over extended period of time compared with CS-g-poly(AA-co-AAm)/PVP/CAM formulation.Conclusion: In the presence of MMT, the effective life time of drug is prolonged, demonstrating asustained release property. The reason is that interlinked porous channels within superabsorbentnanocomposite network hinder penetration of aqueous solutions into hydrogel and subsequentlycause a slower drug release.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.