The incubator is an encased device whose inward ecological system is disconnected from the surrounding climate. It creates an ideal climate for the incubation process and is an indispensable device for premature infants as these children are prone to developing health problems that would affect the conditions of their growth and development. A low-cost, IoT-based autonomous Incubation System that would create an ideal environment for premature children to help them to grow to maturity would be invaluable, especially for rural areas that lack adequate medical facilities. Such a system would significantly reduce the mortality rate of premature infants. This paper focuses on designing a framework for such a system in which the temperature and humidity are autonomously controlled. A secured incubation system was developed using IBM Cloud, IBM Watson IoT platform, and MIT App Inventor.