In this paper, a novel flexible antenna for the new ISM band is proposed. A multi-objective optimization based on DDEA-SE is performed to optimize the antenna bandwidth and gain. The proposed optimized antenna has a 4 dB maximum realized gain and 50% maximum radiation efficiency on the ISM band. A fractal structure is used in this design to achieve a multi-band antenna. The bandwidth of this antenna covers several 5G bands. This multi-band antenna is fabricated on a cotton substrate. This antenna has a small dimension which makes it suitable for 5G applications. The bending tests are performed, and both simulation and measurement results show the good performance of the proposed antenna.

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