This study aims to present a novel Self-regulating and Intelligence Meta-Heuristic-Fuzzy approach (As Methodological Contribution) for integrated and optimal Human Resource Allocation (HRA) in normal and critical conditions at SMEs (As Conceptual Contribution). In this research, a mathematical model of human resource allocation problem is presented, and then Sugeno Fuzzy Inference (SFI) model is used in the tasks rate adjustment layer. The SFI model is the main part of developing Gray Wolf Optimization (GWO) algorithm to reach the integrated and optimal allocation of available human resources under self-regulating attribute in the novel approach. The novel approach has tested and compared to the best researches using data previous researches and by the top five proposed methods in the researches (Includes: SGA, PRS, SRS, MIP, HM) based on three methods of evaluating the quality of solutions (GA-FSGS, MP-FSGS, GA-SGS). The results showed that increase of Ω from 15,000 to 25,000, and HM and SGA clearly performed better than other previous cases in the larger B100 and B200 datasets. Also, it is verified that the method had better results compare to all previous solving methods, and the quality of the solutions have been the best.