Objectives: This case study was designed to evalute the effect of Korean medical treatment on genital ulcer. Methods: This patient was treated with herbal medicine of Palmul-tang (八物 湯), Yongdamsagan-tang (龍膽瀉肝湯), acupuncture and herbal applications. This efficacy of treatment was evaluated with inspection and patient's report. Results: After treatments, the patient's symptoms such as genital ulcer, erythema and swelling were improved. Conclusions: This case report shows that the Korean medical treatment is effective in the treatment of genital ulceration.