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Objectives : The purpose of this study was to investigate the effects of Polygonum tinctoria Niram(PTN) on atopic dermatitis(AD) in hairless mice induced by 2,4-dinitrochlorobenzene(DNCB).Method : They were divided into four group, Nor, Con, 1X and 5X, for evaluating the change of appearance of skin surface, skin hydration, thickness of epidermis and mast cell numbers during 30 days.Results : PTN suppressed symptoms of AD in appearance of skin and increased skin hydration for 1X and 5X. In histopathological examination, 1X and 5X significantly reduced the thickness of epidermis and number of mast cell in dermis. These results suggested that the PTN improved the AD-like symptoms of hairless Mice.

Objectives : Clerodendron trichotomum Thunberg grows wild fields and mountains in South Korea and China.They have been used for anti-hypertension disease. This study was performed in order to observe the effects of Clerodendron trichotomum Thunberg tea on anti-hypertension. Methods : For the study of Clerodendron trichotomum Thunberg tea, we had divided male SHR (Spontaneously Hypertensive Rat) to ten groups. Control group is SHR. The treatment group is SHR which is administered tea extract at dose of 200 mg/kg/day and 500 mg/kg/day orally for 8 weeks. We measured systolic blood pressure, diastolic blood pressure, number of pulse, body weight, total cholesterol and triglyceride from blood serum. Results : The level of systolic and diastolic blood pressure were significantly decreased by 12.5% and 44.9% in Clerodendron trichotomum Thunberg tea groups than control group. Heart rate of Clerodendron trichotomum Thunberg tea groups, 24.5%, was significantly lower than control group. We found that treatment with the water extract from Clerodendron trichotomum Thunberg leave and flower significantly decreased weight of body, total cholesterol and triglyceride to 20.4% and 27.7% compared to untreated control group, significantly (P < 0.05).Conclusions : These results suggest that leaf and flower tea of Clerodendron trichotomum Thunberg tea is effective in prevention and treatment of hypertension and decreasing cholesterol. Long term consumption of Clerodendron trichotomum Thunberg leaf and flower tea can be help in lowering high systolic and blood diastolic pressure, heart rate and blood serum in SHR.