Antibiotics
Antibiotics U 1200Synthesis and Antibacterial Activity of 1β-Methyl-2-(5-substituted thiazolo pyrrolidin-3-ylthio)carbapenem Derivatives. -Among 14 title compounds, derivative (I) is found to be the most active one. -(OH, C.-H.; CHO, H.-W.; BAEK, D.; CHO*, J.-H.; Eur.
Synthesis and Antibacterial Activity of 1β-Methylcarbapenems Having a 2,2-Disubstituted-1,3-diazabicyclo[3.3.0]octan-4-one Moiety and Related Compounds. Part 3. -A variety of novel 1β-methylcarbapenem derivatives bearing a diazabicyclooctanone [cf. (IV)] or diazabicyclononanone moiety [cf. (VII)] are synthesized and evaluated for their in vitro antibacterial activities. Compound (IVc) proves to be the most potent derivative. Moreover, derivative (VIIa) is found to exhibit excellent stability against renal dehydropeptidase-I. -(OH,
Synthesis and Antibacterial Activities of 4-Pyrrolidinylthio Carbapenems: Containing Heteroaromatics as a Side Chain. -A variety of the new carbapenem derivatives (XI) (10 examples) are synthesized and evaluated for their in vitro antibacterial activities. Compounds (XIa) and (XIb) show the most potent activity. -(CHO, H.-W.; OH, C.-H.; LEE, J.-S.; LEE, S.-C.; CHOI, J.-H.; CHO*, J.-H.; Arch.
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