Aims: To evaluate prosthetic maintenance and patients' satisfaction with the BioHPP (biocompatible high-performance polymer) was used as a skeletal substructure for the hybrid (implant fixed detachable) prosthesis versus the BioHPP bar supporting and retaining implant overdenture based on the visual analogue scale (VAS). Materials and Methods: twenty completely edentulous male patients were selected randomly from the outpatient clinic of the Department of Prosthodontics, Faculty of Dentistry, Ain Shams University; the patients complained of ill-fitting mandibular dentures due to ridge atrophy. All patients received new complete dentures; four inter foramina implants were placed using a surgical guide. Three months after osseointegration, the patients divided into two groups received CAD-CAM BioHPP framework hybrid prosthesis (group I) and BioHPP bar supported and retained overdenture (group II). The prosthetic complication was recorded, and the patient's subjective evaluation using a questionnaire based on the VAS includes five points for speech, chewing, comfort, aesthetics, oral hygiene, and general satisfaction was recorded. Results: Patient satisfaction revealed no difference between groups I and II at followup, with both groups highly satisfied after 12 months of follow-up. The general satisfaction for Group I was 4.43 ± 0.34, while that group II was 4.43 ± 0.50. Conclusion: The CAD/CAM BioHPP framework materials offer treatment modalities that are a good alternative for mandibular rehabilitation. Excellent levels of subjective patient satisfaction and prosthetic maintenance during the oral function were seen.