The EAST research program aims to demonstrate steady-state long-pulse advanced high-performance H-mode operations with ITER-like poloidal configuration and RF-dominated heating schemes. Since last IAEA FEC, EAST has been upgraded with all ITER-relevant auxiliary heating and current drive systems, enabling the investigation of plasma profile control by coupling/integration of various combinations. By means of the 4.6 GHz and 2.45 GHz LHCD systems, H-mode can be obtained and maintained at relatively high density, even up to n e ~ 4.5 × 10 19 m-3 , where a current drive effect is still observed. Significant progress has been achieved on EAST, including: i). Demonstration of a steady-state scenario (fully non-inductive with V loop ~ 0.0V at high β P ~ 1.8 and high performance (H 98,y2 > 1.0) in upper single-null (ε ~ 1.6) configuration with the tungsten divertor; ii) Discovery of a stationary ELM-stable H-mode regime with 4.6 GHz LHCD; iii) achievement of ELM suppression in slowly-rotating H-mode plasma with the application of n = 1 and 2 RMPs.

Aimed at high-confinement (H-mode) plasmas in the Experimental Advanced Superconducting Tokamak (EAST), the effect of local gas puffing from electron and ion sides of a lower hybrid wave (LHW) antenna on LHW–plasma coupling and high-density experiments with lower hybrid current drive (LHCD) are investigated in EAST. Experimental results show that gas puffing from the electron side is more favourable to improve coupling compared with gas puffing from the ion side. Investigations indicate that LHW–plasma coupling without gas puffing is affected by the density near the LHW grill (grill density), hence leading to multi-transition of low–high–low (L–H–L) confinement, with a correspondingly periodic characteristic behaviour in the plasma radiation. High-density experiments with LHCD suggest that strong lithiation gives a significant improvement on current drive efficiency in the higher density region than 2 × 1019 m−3. Studies indicate that the sharp decrease in current drive efficiency is mainly correlated with parametric decay instability. Using lithium coating and gas puffing from the electron side of the LHW antenna, an H-mode plasma is obtained by LHCD in a wide range of parameters, whether LHW is deposited inside the half-minor radius or not, implying that a central and large driven current is not a necessary condition for the H-mode plasma. H-mode is investigated with CRONOS.

Gastric cancer is the third most common cause of cancer-related death worldwide. Drug resistance is the main inevitable and vital factor leading to a low 5-year survival rate for patients with gastric cancer. Autophagy, as a highly conserved homeostatic pathway, is mainly regulated by different proteins and non-coding RNAs (ncRNAs) and plays dual roles in drug resistance of gastric cancer. Thus, targeting key regulatory nodes in the process of autophagy by small molecule inhibitors or activators has become one of the most promising strategies for the treatment of gastric cancer in recent years. In this review, we provide a systematic summary focusing on the relationship between autophagy and chemotherapy resistance in gastric cancer. We comprehensively discuss the roles and molecular mechanisms of multiple proteins and the emerging ncRNAs including miRNAs and lncRNAs in the regulation of autophagy pathways and gastric cancer chemoresistance. We also summarize the regulatory effects of autophagy inhibitor and activators on gastric cancer chemoresistance. Understanding the vital roles of autophagy in gastric cancer chemoresistance will provide novel opportunities to develop promising therapeutic strategies for gastric cancer.