Odd ratio for CBZ induced SJS/TEN and HLA-B*15:02 was 609.0 (95% CI: 23-15873; p=0.0002). Molecular modeling studies showed that acetazolamide, ethosuxiamide, lamotrigine, oxcarbazepine, phenobarbital, phenytoin, primidone and sodium-valproate may induce ADR in HLA-B*15:02 carriers alike CBZ. Conclusion. We confirmed HLA-B*15:02 as a predictor of SJS/TEN and recommend pre-screening. Computational prediction of DIHR is useful in personalized medicine.

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Common cause of death in demyelinating disorders such as Multiple sclerosis has been reported to be infections or cardiorespiratory causes. We report 2 patients who were being investigated for Multiple sclerosis and related disorders who had an unexpected sudden death. Our first case is a 26 year old who presented with Optic Neuritis and past history suggestive of Transverse Mellitus and our second case was a 30 year old woman presented with recurrent Optic Neuritis. They were both being assessed for demyelinating disorders and had sudden unexpected death. More research needs to be done to correlate death directly related to demyelinating diseases.