Work to assess the thermal properties of 2butynoic acid (a precursor to acalabrutinib) has revealed the potential for thermal runaway on heating; testing using accelerated rate calorimetry (ARC) showed exothermic onset from 135 °C, precluding short-path distillation as a means of purification. Recrystallization was shown to be effective as an alternative technique to purify the compound and avoid the distillation procedure.

No abstract

XOTES ON THE MANUFACTURE AND UPKEEP OF MtLLING CUTTERS. BY DR. H. T. ASHTON, Member, OF THE ROYAL SMALL ARMS FACTO~;I-, ENFIELD LOCK. Although the system of manufacture of milling cutters detailed in this Paper is suitable for general application, it has been developed more particularly to meet the difficulties of extending the use of high-speed steel to milling cutters of complicated shape, required when cutting to give an accurate finish and a good surface. It is believed that these difficulties have been commonly met with, and that owing to them the general introduction of high-speed steels of the Taylor-White class has, so far, generally proved of less benefit to engineers for milling cutters than for any other form of cutting tool used in engineering workshops. Perhaps the advantages to be obtained by the use of high-speed steels for such cutters are also not so obvious as they are for the heavy lathe or planer tools, where the almost red-hot chips, that they can be made to produce, appeal to the least observant onlooker. When, however, it is considered that this class of steel not only has the property of koeping a cutting edge for a reasonable time when taking very heavy cuts at a previously unattainable speed, but also keeps its cutting edge when used with a moderate out and speed for * See "Modem Machine-Shop Practice," by Joshua Rose, Second Edition, Vol. I, page 37.

No abstract

No abstract