We raise the power from a commercial 10 W frequency comb inside an enhancement cavity and perform multi-photon ionization of gas-phase atoms at 100 MHz for the first time, to the best of our knowledge. An intra-cavity velocity-map-imaging setup collects electron-energy spectra of xenon at rates several orders of magnitude higher than those of conventional laser systems. Consequently, we can use much lower intensities
∼
10
12
W
/
c
m
2
without increasing acquisition times above just a few seconds. The high rate and coherence of the stabilized femtosecond pulses are known to be transferred to the actively stabilized cavity and will allow studying purely perturbative multi-photon effects, paving the road towards a new field of precision tests in nonlinear physics.
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