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Langg&rd, H. Exchungeuble water, sodium and chloride in the skin of mice. Acta physiol. scand. 1965. 64. 263-268. -The exchangeability of water, sodium and chloride in skin has been studied in untreated mice, in mice with localized acute inflammatory edema and in mice with estradiol induced edema of the skin. The total amounts of water and sodium were found to be readily exchangeable whereas 15 per cent of the tissue chloride, in untreated mice, was exchanged a t a much lower rate. The findings in the mice with acute inflammatory edema and in mice treated with estradiol indicated a possible relationship between the slowly exchangeable chloride and the amount of acid mucopolysaccharides in the skin.

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