Ever since the emergence of the COVID-19 outbreak, there have been so many casualties worldwide. According to WHO, more than half a billion people were infected by the virus, of which 6.5 million deaths were counted. However, some already existing antivirals were repositioned and repurposed as anti-COVID-19 therapeutics such as molnupiravir, favipiravir, and ritonavir. The emergency needs to develop effective anti-viral drugs for the treatment of COVID-19 infection Consequently, there arose a need for effective, rapid, accurate, and reliable techniques for the determination of these antivirals. Here in this review, the different reported analytical methods for the quantitative determination of the studied anti-viral drugs were discussed. These reported methods include spectrophotometric methods, spectroflurometric methods, electrochemical methods, and different chromatographic methods, wither the reported method used for the quantitative determination of the studied anti-viral drugs in a single dosage form or in a co-formulated mixture also in different biological fluids and samples.