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In view of the lack of relevant research on CNC grinders in the field of reliability research of CNC machine tools at present, This research collected reliability data based on 19 MSK series grinder machine tools of a machine tool factory., found out the crucial subsystem which is the most important component to the whole, and analyzed the reliability of the subsystem adopting FTA (Fault Tree Analysis) . Statistical researched on 438 reliability data collected, combining with the actual production situation, the results shows that cooling system is the key to the reliability of the whole grinder machine tool. The 29 minimum cut sets obtained by FTA can be adjusted to improve the reliability of the cooling system, what is more, the reliability of grinder machine tool would be improved as well.