No abstract

To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.

is properly cited.Purpose. To investigate the characteristics of silicone oil (SO) emulsification after vitrectomy for rhegmatogenous retinal detachment and their possible correlations with clinical factors. Methods. e first 2 mL of washing out fluid after SO removal was collected, and used for the measurement of the size and number of SO droplets using a Multisizer ® 3 Coulter counter (Beckman Coulter, USA). e correlations between SO droplets and clinical factors were analyzed. Results. A total of 38 patients (23 males, 15 females) who underwent primary PPV with SO injection for RRD and whose retina stayed attached for ≥3 months after SO removal were included in the study. e average number of oil droplets was 1.96 × 10 6 ± 3.95 × 10 6 /mL (range 0.17 × 10 6 to 21.71 × 10 6 /ml), and 80.8% (range 64.23%-99.07%) of the droplets were 1-2 μm in diameter. e total number of emulsified SO droplets was not correlated with any clinical factor (all P > 0.05). When the emulsified SO droplets were divided into groups by their diameter, multiple linear regression revealed that age was negatively correlated with the numbers of 5-7-μm-diameter and 7-12-μm-diameter droplets (both P < 0.05). Patients using antiglaucoma medications had more 5-7-μm-diameter and 7-12-μmdiameter droplets than those not using (all P < 0.05). Conclusion. Using a Multisizer ® Coulter counter, we successfully determined the number and size of SO droplets after emulsification. We found that the number of 5-12-μm-diameter droplets was higher in younger-age patients and was higher in patients using antiglaucoma eyedrops.

<b><i>Introduction:</i></b> We aimed to study the change in the retinal perfusion in Leber’s hereditary optic neuropathy (LHON). <b><i>Methods:</i></b> Fourteen patients (28 eyes) diagnosed with LHON and 14 healthy controls (28 eyes) were enrolled. The retinal vessel densities in the parafoveal and peripapillary areas were measured with optical coherence tomography-angiography. <b><i>Results:</i></b> In the subacute LHON patients, the parafoveal superficial capillary plexus (SCP) and inner retinal thickness (IRT) were significantly reduced in all sectors compared with the controls (all <i>p</i> &#x3c; 0.05), and the radial peripapillary capillary (RPC) network was significantly reduced in the temporal and inferior temporal sectors compared with the controls (<i>p</i> &#x3c; 0.05). In the chronic LHON patients, the SCP and IRT were significantly lower in all sectors than in the controls (all <i>p</i> &#x3c; 0.05), the RPC vessel density and thickness were significantly lower in all sectors than in the controls and lower in the temporal, superior temporal, inferior temporal, and nasal sectors than in the subacute-stage patients (all <i>p</i> &#x3c; 0.05). <b><i>Conclusion:</i></b> The retinal structure and the perfusion of the macular and peripapillary areas are reduced in subacute LHON, and the retinal structure and the perfusion of the peripapillary area are further reduced in chronic LHON.