Since the beginning of 2020, SARS-Cov2 virus has become prevalent, and the virus has varied many times. Even though people paid their most effort to develop the vaccine and specific medicine stuff to fight against this pandemic, the virus seems unstoppable and drives the whole world into a worse situation. Human is facing an unprecedented catastrophe. This article claims the possibility to cease the mutation of the COVID virus in the biological and social aspects. The pathology part states why the virus mutates and how to stop the variation of SARS-Cov2. For the society part, the article tries to talk about the different economic situations and policies to stop the pandemic globally. So this article will get the possibility to cease the mutation of COVID-19 with a comprehensive discussion.